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Blood alcohol testing: how PEth is leading the way

Harriet Challenger, Laboratory Manager (Toxicology) at AlphaBiolabs, breaks down what you need to know about Phosphatidylethanol (PEth) testing and how this – combined with EtG and EtPa hair testing – can give the most conclusive insight into an individual’s drinking behaviour.


















Harriet Challenger, Laboratory Manager (Toxicology) at AlphaBiolabs

Blood alcohol testing is one of the most effective ways to measure chronic and excessive alcohol consumption. But there's one test that stands head and shoulders above the rest.

In courts across the UK, blood alcohol testing is an essential part of the evidential picture, providing an insight into an individual's alcohol consumption.  

In family cases where the safeguarding of children and vulnerable people is paramount, such tests provide a rich source of information, enabling family law professionals to act on urgent welfare needs. 

But when it comes to blood alcohol tests, not all are created equal, with Phosphatidylethanol (PEth) testing providing the most conclusive insight into a person's drinking patterns.

PEth alcohol testing – what makes it so conclusive?

There are four main types of blood alcohol testing that family law professionals should be aware of, all of which can provide a four-week historic overview of alcohol use:

• Phosphatidylethanol (PEth) – a direct biomarker of alcohol, which we will examine in more depth here

• Carbohydrate Deficient Transferrin (CDT)

• Liver Function Test (LFT)

• Mean Corpuscular Volume (MCV)

Unlike CDT, LFT and MCV – all of which are indirect biomarkers of alcohol and whose presence can be affected by pre-existing medical conditions and medications, among other factors – PEth is a direct biomarker of alcohol.

This means that it is only present in the body when alcohol has been consumed. An abnormal phospholipid, it requires ethanol for its production.

PEth production begins as soon as ethanol is consumed and accumulates in the blood with frequent alcohol consumption, giving it a high specificity (48-89 per cent) and sensitivity (88-100 per cent).

Drinking experiments show that PEth can be detected in blood after one to two hours, and for up to 12 days after a single drinking episode. In addition, daily alcohol consumption of more than 60g of ethanol (7.5 units) can clearly be distinguished from lower alcohol consumption. As such, PEth testing can detect chronic and single-drinking episodes.

The wealth of information provided by a PEth test, alongside its conclusiveness, is what makes it the most essential of all blood alcohol tests, enabling us to monitor abstinence, drinking behaviour, or identify relapse – a factor that is especially important when working with families and children affected by alcohol abuse.

PEth analysis is also the only blood alcohol test that can be undertaken during pregnancy or within two months of the birth.

In fact, recognition of the value of PEth testing is on the rise, with sales of such tests having more than doubled year-on-year among the legal profession (AlphaBiolabs sales data, 2020-21).

PEth testing vs hair alcohol testing

PEth is second only to the detection of ethyl glucuronide (EtG) and ethyl palmitate (EtPa): a fatty acid ethyl ester (FAEE) in the hair.

Both EtG and EtPa are direct biomarkers of alcohol and give us a highly accurate insight into patterns of drinking, with a three- or six-month overview of usage. Each is absorbed into the hair via different routes, and their levels can assist in assessing excessive alcohol consumption.

EtG is water soluble, produced in the liver and can be impacted by various hair treatments including excessive washing. EtPa is formed in the sebaceous glands from ethanol diffusing from the blood circulation and then deposited into hair primarily from sebum (from the oil glands on the scalp). EtPa (FAEEs) are lipophilic so while not water soluble, its presence can be affected using alcohol-containing hair products such as sprays, gels, and wax.

Because of their respective strengths and weaknesses, both EtG and EtPA tests should be performed, and their findings used to support each other, as shown in LB Richmond v B & W & B & CB [2010] EWHC 2903 (Fam), where Mr Justice Moylan gave guidance on the evidential worth of hair strand testing. Within his guidance, it was also stressed that hair strand tests should not be used in isolation to reach evidential conclusions.

By performing these tests in conjunction with PEth and other blood tests, a more holistic conclusion can be drawn as to a person's alcohol use.

Getting the full picture

There is no getting around the fact that blood alcohol testing combined with hair testing provides us with the fullest picture from which to draw conclusions.

Using highly accurate scientific analysis and examining the way in which the body absorbs alcohol, a case can be made to protect those in need – and reunite families where abstinence has been achieved. 

Legal clients can claim 20 per cent off all AlphaBiolabs blood alcohol tests until 28th February 2022 by quoting ALC20 when placing an order.

For expert advice and support, call the AlphaBiolabs Customer Services team on 0330 600 1300 or email
testing@alphabiolabs.com and a member of the legal sales team will be in touch.

31/01/2022